Whole Organ Transplantation

Review of Natural History, Benefits and Risk Factors Pediatric Liver Transplantation

Liver or hepatic transplantation (LT) is the replacement of a diseased liver with part or whole healthy liver from another person (allograft). Human liver transplants were first performed by Thomas Starzl in the United States and Roy Calne in Cambridge, England in 1963 and 1967, respectively. Liver transplantation is a viable treatment option for end-stage liver disease and acute liver failure....

The Immunologic Barrier The One-Way Paradigm Rejection Tolerance Graft -versus-Host Disease Clinical Bone Marrow Transplantation Clinical Organ Transplantation The Two-Way Paradigm Whole-Organ Transplantation Whole-Organ Transplantation versus Bone Marrow Transplantation

Transplantation for type 1 diabetes mellitus. Whole organ or islets?

Two types of transplants are offered to patients with complicated insulin dependent diabetes mellitus: a) whole pancreas transplantation, b) pancreatic islet transplantation. A total of 29000 whole pancreas transplantations and 1500 islet transplantations have been performed worldwide until today. Patient survival for whole pancreas recipients is 85% five years after transplantation, whereas ve...

Combating Illegal Organ Transplantation Under International Human Rights Law

Despite the fact that the concepts of organ transplantation and organ trafficking seem two completely distinct categories at first glance, sometimes they overlap with each other. This is especially in cases in which organ transplantation occurs from one country to another and for a financial exchange. There are two general indicators for determining the distinction between organ transplantation...

Enteric Exocrine Drainage

Pancreas transplantation was first attempted in humans by Kelly et al. (1967) and Lillehei et al. (1967). The whole organ was grafted along with variable segments of duodenum and jejunum. The results were poor, and by 1972 the whole organ concept was virtually abandoned for the next decade. Even at the University of Minnesota where Lillehei worked, only one whole pancreas was transplanted betwe...

Predicted lifetimes for adult and pediatric split liver versus adult whole liver transplant recipients.

Split liver transplantation allows 2 recipients to receive transplants from one organ. Comparisons of predicted lifetimes for two alternatives (split liver for an adult and pediatric recipient vs. whole liver for an adult recipient) can help guide the use of donor livers. We analyzed mortality risk for 48,888 waitlisted candidates, 907 split and 21,913 whole deceased donor liver transplant reci...